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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCNX All Species: 21.52
Human Site: S2105 Identified Species: 39.44
UniProt: Q96RV3 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96RV3 NP_055797.2 2341 258676 S2105 P T L G T S H S S H S V Q S G
Chimpanzee Pan troglodytes XP_510039 2300 254005 S2064 P T L G T S H S S H S V Q S G
Rhesus Macaque Macaca mulatta XP_001084081 2342 258864 S2106 P T L G T S H S S H S V Q S G
Dog Lupus familis XP_537501 2332 257280 S2096 P A L G T S H S S H S V Q S S
Cat Felis silvestris
Mouse Mus musculus Q9QYC1 2344 258128 S2108 P T L G T S H S A H S V Q S S
Rat Rattus norvegicus NP_001163818 2343 257924 S2107 P T L G T S H S A H S V Q S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_423893 2312 255194 P2062 G A H P T A L P A A H P P A H
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001923995 2285 252748 Q2056 V Q S G L V R Q S P A R A S V
Tiger Blowfish Takifugu rubipres Q98UF7 1703 191329 Q1476 S Q S S Q S V Q S G L V R H S
Fruit Fly Dros. melanogaster P18490 3433 367590 L2860 T G G E S G D L A P V F I S A
Honey Bee Apis mellifera XP_624687 2092 236172 K1865 V I K S N V L K L W Q R I R R
Nematode Worm Caenorhab. elegans NP_492790 1634 183268 I1407 Q T E R E R A I M N R P N F Q
Sea Urchin Strong. purpuratus XP_001195494 2799 311472 R2162 G S E S G S V R Q T P A H S R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.6 98.7 94.4 N.A. 90.9 91.1 N.A. N.A. 84.9 N.A. 66.7 54.4 29.4 38.7 27.7 35.5
Protein Similarity: 100 98.1 99.4 96.4 N.A. 95.5 95.3 N.A. N.A. 90.8 N.A. 77.7 63 42.9 55.5 41.8 49.2
P-Site Identity: 100 100 100 86.6 N.A. 86.6 86.6 N.A. N.A. 6.6 N.A. 20 20 6.6 0 6.6 13.3
P-Site Similarity: 100 100 100 86.6 N.A. 93.3 93.3 N.A. N.A. 26.6 N.A. 26.6 26.6 20 0 13.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 16 0 0 0 8 8 0 31 8 8 8 8 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 16 8 8 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 8 0 8 0 % F
% Gly: 16 8 8 54 8 8 0 0 0 8 0 0 0 0 24 % G
% His: 0 0 8 0 0 0 47 0 0 47 8 0 8 8 8 % H
% Ile: 0 8 0 0 0 0 0 8 0 0 0 0 16 0 0 % I
% Lys: 0 0 8 0 0 0 0 8 0 0 0 0 0 0 0 % K
% Leu: 0 0 47 0 8 0 16 8 8 0 8 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 0 0 8 0 0 8 0 0 % N
% Pro: 47 0 0 8 0 0 0 8 0 16 8 16 8 0 0 % P
% Gln: 8 16 0 0 8 0 0 16 8 0 8 0 47 0 8 % Q
% Arg: 0 0 0 8 0 8 8 8 0 0 8 16 8 8 16 % R
% Ser: 8 8 16 24 8 62 0 47 47 0 47 0 0 70 31 % S
% Thr: 8 47 0 0 54 0 0 0 0 8 0 0 0 0 0 % T
% Val: 16 0 0 0 0 16 16 0 0 0 8 54 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _